Run 1 of 3. 0 of 312 items. 181 missables still open. 4 endings. About 40h to go.
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End of Zoe has its own save slots and its own route through the swamps around the Baker estate, one way from area to area. Play it first on Normal and fight with your fists only: that earns Promise Kept and The Only Guns You Need in one go, and the clear opens Joe Must Die and the Extreme Challenges (section 17). The five files count toward 100%; the first one starts in your inventory. The effigies are optional: each one carried makes your punches stronger, which helps a lot on a run without weapons. Each area closes behind you, so pick everything up before the boat or the scene that ends it.
The Only Guns You Need is lost the moment you throw a Throwing Spear or set a Stake Bomb: any thrown or placed weapon counts. The gauntlet you find on the Baker estate near the end is fine to use. Gators can't be beaten by hand, so sneak past them, lure them off and climb out of the water (some stop chasing and vanish once you are on land). The four-legged fast Molded are the hardest part: crouch, sidestep their leap, then keep punching. Sneak kills (crouch and attack from behind an enemy that hasn't seen you) save a lot of health.
Joe's House stays behind once Zoe is in the boat. Joe's Note (inside the house, by the front door) and the Boxer Effigy on the drum past the first barrier must be in hand first.
Once you reach Zoe in the Base boat house, a scene plays and the boat ride after it leaves the Base and the Paddle Boat behind. The Orders file in Medical Storage must be read first. Optional: the Boxer Effigies at the path pool, the side storage, the shed, the Paddle Boat roof and the synthesizer bench, and the Champion Effigy in the 1F air duct.
The boat leaves you in Quarantine Area 1. Crawl under the old building: a toy gator surfaces first, and the real one behind it will likely land a hit when you have no spear. Cross the big lake platform by platform to the large house at the far end; its side entrance has just one gator, so come at it from the left. Stairs lead up into Quarantine Area 2: cross the rickety walkway (a fall means gators), fight off the ambush in the first house and sneak through the second, then follow the winding path and broken walkways to the end. There Molded hide behind cover, a fast Molded bursts from a shack on the right, and a Double Blade Molded guards the last yellow barrier.
Reaching Zoe in the church ends the swamp half: you wake up somewhere else with nothing in your pockets, and everything you carried waits in an item box much later. The swamp can't be reached again. Optional: the Champion Effigies in the Quarantine Area 1 fridge and the Quarantine Area 2 tree, and the Boxer Effigies in the church save shack and at the lamppost.
Walking up to Zoe in the Main House hall starts the last fight, and the run ends after it. Both files in the Yard tent (the Analysis Report and the AMG-78) must be read first. Optional: the Champion Effigy in the Old House room with the collapsed floor and the Boxer Effigy on the Old House bridge. Fists and the gauntlet only, to the end.