The opening chapter: the gang shelters from a blizzard in Colter and Arthur rides out on six story missions before the camp moves down to the Heartlands.
Mahogany Bay Tennessee Walker (unique horse)ItemMissablePoint of no return
Location
Grizzlies West · Adler Ranch – The skittish, well-bred horse Arthur calms in the Adler Ranch barn and ties to the hitching post during Outlaws from the West.
Why you can lose it
One of a kind: lost for good if it is sold or dies, and the route counts it gone once the last Chapter 6 mission starts.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Free roam opens. Valentine and the camp at Horseshoe Overlook, the first strangers and camp chores, the Jack Hall Gang treasure, a bear hunt in the Grizzlies and the first honor missions.
Dutch's Speech NotesCollectibleMissablePoint of no return
Location
Heartlands · Horseshoe Overlook – Search the wooded edge of the Horseshoe Overlook camp for a broken-down wagon; the notes are on the table next to it.
Why you can lose it
Chapter 2 only: gone once "A Strange Kindness" moves the gang away from Horseshoe Overlook.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
Pen (Jimmy Brooks)CollectibleMissablePoint of no return
Location
Heartlands · Caliban's Seat – At the end of "Polite Society, Valentine Style", choose to pull Jimmy Brooks up from the cliff edge on Caliban's Seat; he gives you the pen before riding off.
Why you can lose it
Lost if Jimmy Brooks falls: stamping on his hand or leaving him ends the offer.
Point of no return
Finishing "Polite Society, Valentine Style" without pulling Jimmy Brooks up.
Charity Handbill (Thomas Downes)CollectibleMissablePoint of no return
Location
Heartlands · Valentine – From your first visits to Valentine, Downes stands at his fundraiser table near the stable at the north-west end of town. Talk to him and take the handbill off the table before you walk on.
Why you can lose it
Lost if you leave Downes's table without it: you can meet him there only once.
Point of no return
Leaving Thomas Downes's charity table by the Valentine stable without the handbill (you can meet him there only once).
Item request: Bill, Hair PomadeOtherMissablePoint of no return
Location
Heartlands · Horseshoe Overlook – Buy Hair Pomade at the Valentine general store now. Back at camp, Bill calls Arthur over from his chair (8:00 to 20:00); talk to him to hand it over.
Why you can lose it
Lost once "Banking, The Old American Art" starts: camp requests end with the camp chapters.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Good, Honest, Snake OilQuest stepMissablePoint of no return
Location
Heartlands · Valentine – Sheriff Malloy in Valentine's sheriff's office gives it (the skull icon). Allbright is in the gorge north of Valentine by the Dakota River; bring him back alive and hogtied.
Why you can lose it
Taken as lost when "A Strange Kindness" starts; other lists keep it open until Chapter 5 or 6, but do it now.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
Bring in a quack medicine seller for the Valentine sheriff; it opens bounty hunting and counts as an honor mission for Lending a Hand. Gold: keep Benedict Allbright from going over the cliff; hogtie him within 1:15; deliver him within 1:30.
Granger's RevolverWeaponMissablePoint of no return
Location
Heartlands · Granger's Hoggery – Pick it up from Granger's body or the ground beside it straight after the duel. If you shot it out of his hand, wound him before the kill, or it may not drop.
Why you can lose it
Lost if you leave the hoggery after the duel without picking it up.
Point of no return
Leaving Granger's Hoggery after the duel without looting Granger's body.
Item request: Susan, two seasoning herbsOtherMissablePoint of no return
Location
Heartlands · Horseshoe Overlook – Susan stops you in camp and asks for two of any seasoning herb: Oregano, Wild Mint or Creeping Thyme. All three are common in grassland everywhere; pick two and talk to her.
Why you can lose it
Lost once "Banking, The Old American Art" starts: camp requests end with the camp chapters.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Heartlands · Valentine – In "Exit Pursued by a Bruised Ego" you lead the black Shire to the Valentine stable to sell. Choose to stable it instead, and never sell it or let it die.
Why you can lose it
Gone for good if it is sold or dies, and horses left in stables are lost after Chapter 6.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Money Lending and Other Sins I & IIQuest stepMissablePoint of no return
Location
Heartlands · Horseshoe Overlook – Strauss gives it in camp. Lasso Chick Matthews off his horse at Guthrie Farm and he hands over a map to money hidden in a tree; Mr. Wróbel is at his Painted Sky farm in Big Valley, and Lilly Millet at Emerald Ranch, where her man Cooper picks a fight.
Why you can lose it
Lost when "A Strange Kindness" moves the camp.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
Give to the PoorAchievementMissablePoint of no return
Location
Heartlands · Horseshoe Overlook – Use the tithing box beside Dutch's tent. The two Jack Hall gold bars from O'Creagh's Run clear the $250 at once.
Why you can lose it
Lost once "Banking, The Old American Art" starts: the camp chapters end and the box goes.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Money Lending and Other Sins IIIQuest stepMissablePoint of no return
Location
Heartlands · Downes Ranch – Strauss gives it in camp once a debt is in the box. Thomas Downes is in the garden at Downes Ranch in the Heartlands, east of Wallace Station.
Why you can lose it
Lost when "A Strange Kindness" moves the camp.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
We Loved Once and True I & IIQuest stepMissablePoint of no return
Location
Heartlands · Chadwick Farm – Susan tells you a letter from Mary has come; read it in Arthur's tent, then ride to Chadwick Farm near Valentine and knock on the door.
Why you can lose it
Lost when "A Strange Kindness" moves the camp.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
Arthur's old love Mary Linton asks for help with her brother; an honor mission for Lending a Hand. Agree to help her: it raises honor and opens part III.
We Loved Once and True IIIQuest stepMissablePoint of no return
Location
Cumberland Forest · Cumberland Forest – It starts in Cumberland Forest, where the Chelonians camp on a cliff, and ends with Jamie at Valentine Station.
Why you can lose it
Lost when "A Strange Kindness" moves the camp, and it only opens if Arthur agreed to help Mary.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
Bring Mary's brother Jamie home from a religious order; an honor mission for Lending a Hand. Gold: talk the Chelonians into letting Jamie go peacefully; return Jamie to Mary within 2:00.
Item request: Pearson, a rabbit carcassOtherMissablePoint of no return
Location
Heartlands · Horseshoe Overlook – Pearson asks between 8:00 and noon while cooking at the food tent; ride in and out of camp until he does. Bring a whole, unskinned rabbit, pick "Give request" when you talk to him, then put it on his table. Save first: the reward sometimes fails.
Why you can lose it
Lost at the move to Clemens Point: it is meant to run to Chapter 4, but it hasn't been seen after Chapter 2.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
Chapter 2: Emerald Ranch, Strawberry and the move south
The rest of Chapter 2: Emerald Ranch and the oil job into Lemoyne, a long stay in Big Valley around Strawberry, then the last Valentine jobs before the gang moves south. It ends at the Chapter 2 point of no return.
Item request: Charles, moonshineOtherMissablePoint of no return
Location
Heartlands · Emerald Ranch – Buy moonshine from the Emerald Ranch fence (south side, by the barn) and give it to Charles at camp once he asks. His later request is for Oleander Sage.
Why you can lose it
Lost once "Banking, The Old American Art" starts: camp requests end with the Chapter 4 camp.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Summary
Charles's first camp request, for Fire Arrows; it counts toward Errand Boy (camp requests work as the camp callout in the previous section explains).
Item request: Mary-Beth, a fountain penOtherMissablePoint of no return
Location
Roanoke Ridge · Osman Grove – The pen is in the Osman Grove house, in the nightstand drawer (it may sit on a table instead); take the Penny Dreadful comic there too, for Jack's request later. Give the pen to Mary-Beth at camp once she asks.
Why you can lose it
Lost once "A Strange Kindness" starts: this giver asks only at the Horseshoe Overlook camp.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
Summary
Mary-Beth's camp request, rewarded with a ring. Jimmy Brooks's pen from Valentine does not fill it.
Pouring Forth Oil IIQuest stepMissablePoint of no return
Location
Heartlands · Cornwall Kerosene & Tar – Take it from John right after part I. The closest wagon is at Cornwall Kerosene & Tar in the Heartland Oil Fields; drive it to the marked drop-off at Old Trail Rise.
Why you can lose it
Lost if the in-game day (perhaps only 4 hours) passes after part I before you start it: John steals the wagon himself.
Point of no return
Letting the in-game day (strictly, 4 in-game hours) pass after "Pouring Forth Oil I" without starting part II: John steals the wagon himself.
Item request: Javier, Oleander SageOtherMissablePoint of no return
Location
Bayou Nwa – Oleander Sage grows in the Bayou Nwa swamps: ride on from Dewberry Creek into the bayou and pick some for Charles too. Give it to Javier at camp.
Why you can lose it
Lost once "A Strange Kindness" starts: this giver asks only at the Horseshoe Overlook camp.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
Summary
Javier's camp request, rewarded with Poison Throwing Knives.
Item request: Charles, Oleander SageOtherMissablePoint of no return
Location
Bayou Nwa – Use sage from the same Bayou Nwa trip and give it to Charles at camp when he asks.
Why you can lose it
Lost once "Banking, The Old American Art" starts: camp requests end with the Chapter 4 camp.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Item request: Jack, a Penny Dreadful comicOtherMissablePoint of no return
Location
Heartlands · Horseshoe Overlook – Jack asks for it during A Fisher of Men. Give him the comic from the Osman Grove house; others lie at Clawson's Rest north-west of Valentine, the Pleasance schoolhouse and Downes Ranch.
Why you can lose it
Lost once "A Strange Kindness" starts: this giver asks only at the Horseshoe Overlook camp.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
Heartlands · Horseshoe Overlook – Pops on the fifth delivery. By now eight requests above can be handed in (Bill, Susan, Charles's two, Mary-Beth, Javier, Jack's comic and Abigail), not counting Pearson's rare rabbit, and every later request counts too.
Why you can lose it
Lost once "Banking, The Old American Art" starts (requests after the story may also count; don't wait for them).
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Summary
Bronze trophy for handing in five camp item requests from gang members.
Bucket Hat (Appleseed Timber Co. worker, Monto's Rest)ArmorMissablePoint of no return
Location
Big Valley · Monto's Rest – Ride to Monto's Rest, north-east of Strawberry, where the timber company's workers are. Knock one worker's hat off and pick it up.
Why you can lose it
Lost when "That's Murfree Country" starts in Chapter 6, or sooner if the Appleseed Timber camp finishes all three of its stages.
Point of no return
Starting "That's Murfree Country", the last Chapter 5 mission (the strictest reading of "until Chapter 6")
Summary
A hat the Appleseed Timber Co. workers wear; knocked off and picked up, it stays in the wardrobe.
Letter from St. Luke's AcademyCollectibleMissablePoint of no return
Location
Big Valley · Monto's Rest – The timber camp changes over separate visits (the foreman short of supplies, then a tree pinning a worker, then wolves), so look in whenever you pass Monto's Rest. On the wolf visit, kill the wolves and loot the two mauled workers, which costs no honor; one of them, at random, has the letter.
Why you can lose it
Lost once the timber camp packs up after its last stage, and at the latest when "That's Murfree Country" starts.
Point of no return
Starting "That's Murfree Country", the last Chapter 5 mission (the strictest reading of "until Chapter 6")
Wedding Certificate (Jim Peyton's wagon)CollectibleMissablePoint of no return
Location
Big Valley · Monto's Rest – Near the timber camp, a wagon lies wrecked at the foot of the Monto's Rest cliff, just north-east of Strawberry (it may instead turn up east of Lenora View, the cabin north of town, or only as a chance encounter). The certificate is in the lockbox on the wreck.
Why you can lose it
Loot the wreck the first time you find it, since it can be missed if left; the route counts it lost once "A Strange Kindness" starts.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
Liberty Hat (coach guards)ArmorMissablePoint of no return
Location
Big Valley · Near Strawberry – In An American Pastoral Scene, one of the mounted guards around the coach may wear it (at random): once they are down, step off and pick it up before you rejoin Micah. Missed it? The hogtied man at the end of the stranger mission A Fine Night For It, by Lagras in Chapter 3, may wear it too.
Why you can lose it
Only two places give it: a coach guard here, at random, and the hogtied man in "A Fine Night For It"; once that stranger mission ends, it is gone.
Point of no return
Finishing "A Fine Night For It": the hogtied man is the Liberty Hat's last chance
Letter to Mayor Timmins from BelindaCollectibleMissablePoint of no return
Location
Big Valley · Strawberry – While you are in Strawberry for Joshua Brown, Mayor Nicholas Timmins (top hat, blue frock coat) greets visitors at the Welcome Center from 8:00 to 20:00. Knocking out a friendly townsman costs honor and can make you Wanted, so save first, then knock him out and loot the letter.
Why you can lose it
Lost once all three of his meetings are used up without looting him (the strictest reading).
Point of no return
Using up Mayor Timmins's third and last meeting in Strawberry without looting the letter from him.
Item request: Dutch, a pipeOtherMissablePoint of no return
Location
Big Valley · Vetter's Echo – The pipe is in the Vetter's Echo cabin; it may instead be in a hut east of Pronghorn Ranch. Give it to Dutch at camp.
Why you can lose it
Lost once "Banking, The Old American Art" starts: camp requests end with the Chapter 4 camp.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Summary
Dutch's camp request, rewarded with the Vaquero Rider Spurs.
Vaquero Rider Spurs (Dutch's pipe request reward)CollectibleMissablePoint of no return
Location
Heartlands · Horseshoe Overlook – Dutch hands them over at camp when you give him the pipe.
Why you can lose it
Lost once "Banking, The Old American Art" starts: Dutch's pipe request ends with the camp chapters.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Item request: Lenny, a pocket watchOtherMissablePoint of no return
Location
Big Valley · Vetter's Echo – Take the watch from the Vetter's Echo cabin, or buy or loot one; a hut close to Pronghorn Ranch may also have one lying on its table. Give it to Lenny at camp.
Why you can lose it
Lost once "Banking, The Old American Art" starts: camp requests end with the Chapter 4 camp.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Summary
Lenny asks at night (20:00 to 03:00) for a pocket watch; he gives Dynamite for it.
Watson's Scrapbook PageCollectibleMissablePoint of no return
Location
Big Valley · Watson's Cabin – From part II's spot, ride back to Watson's Cabin a day or more after your first visit: the four sons attack at the door, then their mother comes at you. Kill the sons but knock out or hogtie Mama Watson, and return at least a day later: the page is on the kitchen table.
Why you can lose it
No source gives a deadline, so the route counts it lost once "A Strange Kindness" starts: make all three visits in Chapter 2.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
Item request: Sean, Kentucky BourbonOtherMissablePoint of no return
Location
Heartlands · Horseshoe Overlook – Once Sean is back in camp after "The First Shall Be Last", he asks for it while he works on fire bottles near the tents around the campfire (8:00 to 20:00). Any general store sells the bourbon; talk to him to hand it over.
Why you can lose it
Lost when "A Strange Kindness" moves the camp: the request has only been seen in Chapter 2.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
Companion activity, Horseshoe Overlook (Charles's bison hunt or Javier's homestead robbery)OtherMissablePoint of no return
Location
Heartlands · Horseshoe Overlook – Take Charles's bison hunt or Javier's homestead robbery when one is offered at camp; if neither is, sleep or play on and check again. Charles's hunt also gives the Poison Throwing Knife pamphlet; table games may not count.
Why you can lose it
Lost once "A Strange Kindness" starts: the Horseshoe Overlook activities leave with the camp.
Point of no return
Starting "A Strange Kindness": the gang leaves Horseshoe Overlook for Clemens Point.
Summary
Friends With Benefits needs one companion activity in each of the three camps; this is the Horseshoe Overlook one.
Newsboy Cap (Cornwall's men)ArmorMissablePoint of no return
Location
Heartlands · Valentine – In the Valentine shoot-out near the end of The Sheep and the Goats, Cornwall's henchmen wear it (often the one on the balcony): kill one and pick up the glowing cap before you run for the cart. Missed it? His men wear it again in An Honest Mistake (Chapter 3) and in one Chapter 6 mission, and some Cornwall oil-wagon drivers wear it until the end of Chapter 6.
Why you can lose it
Only Cornwall's men wear it: in three story missions and, at random, on his oil-wagon drivers until the end of Chapter 6; after that it is gone.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
The gang's first weeks in Lemoyne: Rhodes and its gunsmith, Billy Midnight's train duel, the Grays' courtship errands, the bayou strangers and the Scarlett Meadows homestead stashes.
Son's Drawing (Jasper Feeney)CollectibleMissablePoint of no return
Location
Scarlett Meadows · Rhodes – After the basement job above, the gunsmith stands by while you loot. Getting the drawing means knocking him out (he fights back once attacked), which costs honor and can make you Wanted: save first, then loot it from his body.
Why you can lose it
One list keeps it to Chapters 2 and 3, so the route counts it lost once "Blood Feuds, Ancient and Modern" starts; another says it never goes.
Point of no return
Starting "Blood Feuds, Ancient and Modern" (it runs straight into "The Battle of Shady Belle"; Money Lending IV taken at the earliest claimed deadline)
Letter to Nigel from TomCollectibleMissablePoint of no return
Location
Scarlett Meadows · Rhodes – Nigel (straw boater, bright yellow patterned vest) turns up in Rhodes, Saint Denis, Roanoke Ridge and Blackwater; no source fixes when. Whenever you meet him, save, knock him out and loot the letter: knocking out a friendly stranger costs honor and can make you Wanted.
Why you can lose it
Lost once all six of his meetings (four early on, two much later) are used up without looting him.
Point of no return
Using up Nigel's sixth and last meeting without looting the letter from him.
Scarlett Meadows · The train from Rhodes – Straight after the duel, before you step off the train, loot the pistol from his body and take the photo for Levin.
Why you can lose it
Lost if you leave the train after the duel without picking it up.
Point of no return
Leaving the train after the duel without picking up Midnight's Pistol.
The Course of True Love IQuest stepMissablePoint of no return
Location
Bayou Nwa · Caliga Hall – Ride to Caliga Hall, the Gray family's estate east of Rhodes, and go in by the front gate to meet Beau. Take his letter to Penelope at the gazebo at Braithwaite Manor.
Why you can lose it
Lost once "Blood Feuds, Ancient and Modern" starts, and Lending a Hand only counts it played in the story.
Point of no return
Starting "Blood Feuds, Ancient and Modern" (it runs straight into "The Battle of Shady Belle"; Money Lending IV taken at the earliest claimed deadline)
The Course of True Love IIQuest stepMissablePoint of no return
Location
Scarlett Meadows · Braithwaite Manor – Talk to Beau at Caliga Hall again once part I is done; the mission ends with a quiet approach through the Braithwaite Manor grounds.
Why you can lose it
Lost once "Blood Feuds, Ancient and Modern" starts, and Lending a Hand only counts it played in the story.
Point of no return
Starting "Blood Feuds, Ancient and Modern" (it runs straight into "The Battle of Shady Belle"; Money Lending IV taken at the earliest claimed deadline)
The Course of True Love IIIQuest stepMissablePoint of no return
Location
Scarlett Meadows · Bolger Glade – Talk to Beau at Caliga Hall again; the meeting place is Bolger Glade in Scarlett Meadows.
Why you can lose it
Lost once "Blood Feuds, Ancient and Modern" starts, and Lending a Hand only counts it played in the story.
Point of no return
Starting "Blood Feuds, Ancient and Modern" (it runs straight into "The Battle of Shady Belle"; Money Lending IV taken at the earliest claimed deadline)
Item request: Tilly, a necklaceOtherMissablePoint of no return
Location
Scarlett Meadows · Clemens Point – Tilly asks while you play her dominoes game at Clemens Point; talk to her afterwards with a necklace in your satchel. Necklaces turn up in safes, lockboxes and homestead stashes like the ones above.
Why you can lose it
Lost once "Blood Feuds, Ancient and Modern" starts: the gang leaves Clemens Point and the request goes with it.
Point of no return
Starting "Blood Feuds, Ancient and Modern" (it runs straight into "The Battle of Shady Belle"; Money Lending IV taken at the earliest claimed deadline)
Summary
A Chapter 3 camp request; the reward is two Health Cures.
Item request: Hosea, two American GinsengOtherMissablePoint of no return
Location
Scarlett Meadows · Clemens Point – When Hosea asks at Clemens Point, pick two American Ginseng on your rides and hand them over by talking to him. No fixed spot: gather it wherever you find it growing.
Why you can lose it
Lost once "Blood Feuds, Ancient and Modern" starts: the gang leaves Clemens Point and the request goes with it.
Point of no return
Starting "Blood Feuds, Ancient and Modern" (it runs straight into "The Battle of Shady Belle"; Money Lending IV taken at the earliest claimed deadline)
Summary
A Chapter 3 camp request; the reward is a Potent Health Cure.
Item request: Kieran, two Burdock RootOtherMissablePoint of no return
Location
Scarlett Meadows · Clemens Point – Kieran asks between 12:00 and 18:00 at Clemens Point. Burdock Root grows along the Flat Iron Lake shore by camp; pick two and give them to him.
Why you can lose it
Lost once "Blood Feuds, Ancient and Modern" starts: the gang leaves Clemens Point and the request goes with it.
Point of no return
Starting "Blood Feuds, Ancient and Modern" (it runs straight into "The Battle of Shady Belle"; Money Lending IV taken at the earliest claimed deadline)
Summary
A Chapter 3 camp request; the reward is a Horse Stimulant and the Horse Meal pamphlet.
Chapter 3: Valentine, Big Valley and the Braithwaite feud
The rest of Chapter 3: Bill's Valentine bank job, a loop through the Heartlands for strangers, requests and challenges, the Gray and Braithwaite jobs around Rhodes, a Big Valley trip, and the chapter's last missions.
Item request: Sadie, a harmonica (Granger's Hoggery)OtherMissablePoint of no return
Location
Heartlands · Granger's Hoggery – From Horseshoe Overlook, ride down to Flatneck Station and on to Granger's Hoggery, just east of it. The harmonica is on a shelf in the hut. Give it to Sadie at Clemens Point once she asks (from Further Questions of Female Suffrage on).
Why you can lose it
Sadie's request belongs to Chapter 3: at the strictest reading it is gone once 'Blood Feuds, Ancient and Modern' starts.
Point of no return
Starting "Blood Feuds, Ancient and Modern" (it runs straight into "The Battle of Shady Belle"; Money Lending IV taken at the earliest claimed deadline)
Summary
Sadie asks for a harmonica and gives you gun oil for it. Each delivered request counts toward Errand Boy.
Item request: Molly, a pocket mirror (Martha's Swain)OtherMissablePoint of no return
Location
Grizzlies East · Martha's Swain – On the nightstand inside the Martha's Swain hut. Give it to Molly at Clemens Point once she asks.
Why you can lose it
Molly's request is Chapter 3 only: it is gone once 'Blood Feuds, Ancient and Modern' starts.
Point of no return
Starting "Blood Feuds, Ancient and Modern" (it runs straight into "The Battle of Shady Belle"; Money Lending IV taken at the earliest claimed deadline)
Summary
Molly asks for a pocket mirror and gives you a cigar. It counts toward Errand Boy.
Rare Rolling Block RifleWeaponMissablePoint of no return
Location
Scarlett Meadows · Braithwaite Manor – Near the end, bounty hunters open fire from a barn near Braithwaite Manor. Kill the sniper in the barn (the one who runs back inside once the other two fall) and take the rifle from him before you ride off.
Why you can lose it
Lost when 'Magicians for Sport' ends: a replay adds its Compendium entry, never the rifle.
Point of no return
Finishing "Magicians for Sport"
Summary
A unique sniper rifle that can't be customised, and a Compendium weapon.
Companion activity, Clemens Point (fishing, or Sean's or Bill's coach robbery)OtherMissablePoint of no return
Location
Scarlett Meadows · Clemens Point – At Clemens Point, join Javier's or Kieran's fishing trip, or Sean's or Bill's coach robbery (open since Friends in Very Low Places); skip table games, which may not count. Don't rely on Sean's home robbery, whose target is Lonnie's Shack, already robbed. If none is offered, sleep or move the story on and check again.
Why you can lose it
Clemens Point's activities end when the gang leaves the camp, once 'Blood Feuds, Ancient and Modern' starts.
Point of no return
Starting "Blood Feuds, Ancient and Modern" (it runs straight into "The Battle of Shady Belle"; Money Lending IV taken at the earliest claimed deadline)
Item request: Pearson, a naval compass (Braithwaite Manor boathouse)OtherMissablePoint of no return
Location
Scarlett Meadows · Braithwaite Manor – In the Braithwaite Manor boathouse by the north dock, while you're at the manor for Hosea. Pearson asks for it while you play poker with him at camp; hand it over then.
Why you can lose it
At the strictest reading Pearson asks only in Chapters 2 and 3, so it is gone once 'Blood Feuds, Ancient and Modern' starts; it may instead stay open through Chapter 4.
Point of no return
Starting "Blood Feuds, Ancient and Modern" (it runs straight into "The Battle of Shady Belle"; Money Lending IV taken at the earliest claimed deadline)
Summary
Pearson asks for a naval compass and gives you Guarma Rum. It counts toward Errand Boy.
Money Lending and Other Sins IVQuest stepMissablePoint of no return
Location
Scarlett Meadows · Rhodes – Strauss (S) gives it at Clemens Point. Gwyn Hughes is at the Rhodes undertaker, and his part ends in the First Church of Rhodes graveyard. Winton Holmes is camped north of Strawberry in Big Valley.
Why you can lose it
At the strictest reading it is gone once 'Blood Feuds, Ancient and Modern' starts; it may last into Chapter 4.
Point of no return
Starting "Blood Feuds, Ancient and Modern" (it runs straight into "The Battle of Shady Belle"; Money Lending IV taken at the earliest claimed deadline)
Summary
Strauss sends Arthur after two more debtors. An optional honor mission that Lending a Hand needs; it has no medal.
The first half of Chapter 4: the move to Shady Belle, the first visits to Saint Denis and its strangers, Bronte's errand, Mary's father, the rescue at Radley's House, then a Scarlett Meadows loop for bounties, Strauss's last Chapter 4 debt, Old Harry Fen, Braithwaite Manor and Bayall Edge, and Professor Bell's moonshine.
Chelonian Handbill (Anders Helgerson)CollectibleMissablePoint of no return
Location
Bayou Nwa · Saint Denis – Helgerson, a clean-shaven man in a white suit, preaches on the Saint Denis streets near Angelo Bronte's walled mansion, which the gang visits later in this section; he may instead be elsewhere in the city. Talk to him and accept the pamphlet when he offers it.
Why you can lose it
Lost after Chapter 6: Helgerson offers the pamphlet only at this first meeting.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
A one-off pamphlet from Anders Helgerson, a street preacher for the turtle-worshipping Chelonians. Meeting him also counts as one of the street characters 100% asks for.
Help a Brother OutQuest stepMissablePoint of no return
Location
Bayou Nwa · Saint Denis – Brother Dorkins stands in eastern Saint Denis under a stranger icon (BD once Swanson mentions him at camp). Donate when he asks, then go to the pawnbroker fence at the market: check the bookshelf and pull it aside. Back with Dorkins, tell him to keep the dollar for the poor (more honor).
Why you can lose it
Lost once "Banking, The Old American Art" starts: this honor mission belongs to Chapter 4, and Lending a Hand needs it.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
A monk asks Arthur to look into children held at a shop; an optional honor mission that Lending a Hand needs. Gold: find the captives without threatening the shopkeeper; finish inside 2:45.
Fundraiser: donate $20Quest stepMissablePoint of no return
Location
Bayou Nwa · Saint Denis – Her table is outside a small hall in north-west Saint Denis, a short walk from the tailor's. Robbing the collection box makes you Wanted and drains honor, so just hand over the $20.
Why you can lose it
Lost after Chapter 6: the fundraiser is gone from then on.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Brothers and Sisters, One and AllQuest stepMissablePoint of no return
Location
Bayou Nwa · Saint Denis – A few in-game hours after Help a Brother Out, BD marks the small church in the north of the city. Chase the boy (at the crossroads by the hurt man, take the right-hand path), shake off the lawmen a passer-by sets on you, and hand the crucifix back to the sister at the cathedral.
Why you can lose it
Lost once "Banking, The Old American Art" starts: this honor mission belongs to Chapter 4, and Lending a Hand needs it.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Dorkins introduces Arthur to Sister Calderón, and a boy runs off with her crucifix; another optional honor mission for Lending a Hand. Gold: reach the kid inside 19 seconds.
Item request: Hosea, "The Case of the Shrew in the Fog" (Hagen Orchards)OtherMissablePoint of no return
Location
Bayou Nwa · Hagen Orchards – Ride out of Saint Denis into the bayou north-west of the city to the house at Hagen Orchards; the book lies on a table inside. Hand it to Hosea at camp once he has asked (see Camp: Shady Belle).
Why you can lose it
Lost once "Banking, The Old American Art" starts: camp requests end with the Chapter 4 camp.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Summary
Hosea asks for the next book in his detective series and gives you Predator Bait. It counts toward Errand Boy.
Ornate Dagger (Saint Denis vampire)WeaponMissablePoint of no return
Location
Bayou Nwa · Saint Denis – Pick it up from the ground beside his body as soon as he falls. Rarely only his victim's corpse appears, and the dagger can't be had then.
Why you can lose it
Lost if you leave without picking it up after the kill, or if you go to the meeting while Wanted.
Point of no return
Leaving the vampire's alley without picking up the Ornate Dagger (going to the meeting while Wanted may also lock the encounter)
Fatherhood and Other DreamsQuest stepMissablePoint of no return
Location
Bayou Nwa · Saint Denis – After Angelo Bronte, Mary's letter (ML) waits in Arthur's room at Shady Belle; meet her at the hotel in Saint Denis. Pay the $100 for the brooch (beating the buyer gives no honor, killing him costs it), and accept the theatre. The buyer's coach holds a Naval Compass, a fallback if Pearson still wants one.
Why you can lose it
Lost once "Banking, The Old American Art" starts: this honor mission belongs to Chapter 4, and Lending a Hand needs it.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Mary Linton asks Arthur to help with her father, who is about to sell her mother's brooch; an optional honor mission for Lending a Hand. Gold: take the wagon to the secluded spot inside 1:45; take Mary to the theater.
The Mercies of Knowledge I-IIQuest stepMissablePoint of no return
Location
Scarlett Meadows · Rhodes – You met Bell in north Saint Denis (part I, see The Artist's Way I). Now ask Alden, the clerk at Rhodes station on the west side of town, about a big moonshine delivery (part II).
Why you can lose it
Lost once "Banking, The Old American Art" starts, at the strictest reading; the latest reading keeps the strand open until late in Chapter 6.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Money Lending and Other Sins VQuest stepMissablePoint of no return
Location
Scarlett Meadows · Catfish Jacksons – Ride back to Shady Belle for Strauss, then to Catfish Jacksons, a homestead on the Lannahechee south of Rhodes (robbing or hurting the family before this cancels it). Algie attacks you indoors: beat him with your fists, and his son Nate gives up the money in his footlocker.
Why you can lose it
Lost once "Banking, The Old American Art" starts: this honor mission belongs to Chapter 4, and Lending a Hand needs it.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Letter to Nate from MommaCollectibleMissablePoint of no return
Location
Scarlett Meadows · Catfish Jacksons – Search the cabin's rooms while you are inside for Money Lending V; the letter is somewhere in the house.
Why you can lose it
Counted lost when Chapter 4 ends, at the strictest reading; it is gone for good once Algie and Nate are both dead.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
POI: Braithwaites' SecretAreaMissablePoint of no return
Location
Scarlett Meadows · Braithwaite Manor – From Rhodes, ride south-east to Braithwaite Manor after dark, since guards may be about. On the manor's east side, by the houses on the water, head south into the scrub toward a girl's voice and inspect the small white outhouse it comes from; it may instead be on the west side.
Why you can lose it
It can only be sketched before the end of Chapter 6: after that the outhouse gives no inspect prompt.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Summary
A point of interest the Braithwaites kept hidden: someone shut away in an outhouse near the manor.
Catherine's BroochHidden spoiler – activate to revealCollectibleMissablePoint of no returnMinor spoiler
Location
Scarlett Meadows · Braithwaite Manor – While you are at Braithwaite Manor, search the burnt-out house for Catherine Braithwaite's body and loot the brooch from it.
Why you can lose it
No source gives a deadline for her body, so the route counts it lost once "Banking, The Old American Art" starts, the end of the chapter where you find it.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Summary
A one-off valuable on Catherine Braithwaite's body, which lies in the burnt-out manor after the feud.
The Mercies of Knowledge III: moonshine wagonQuest stepMissablePoint of no return
Location
Bluewater Marsh · North of Saint Denis – From Bayall Edge, ride east to Saint Denis and out on the road north toward Bluewater Marsh. Once you cross the wooden bridge north of the city, the wagon rolls up with two men aboard and two riders: kill all four with nobody watching and drive it south to Bell.
Why you can lose it
Lost once "Banking, The Old American Art" starts, at the strictest reading; the latest reading keeps the strand open until late in Chapter 6.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
The Mercies of Knowledge IV-V: permit and posterQuest stepMissablePoint of no return
Location
Bayou Nwa · Saint Denis – At the police station in south-west Saint Denis, Chief Lambert sells the permit for $100 (haggle it down; demanding it costs $150). Bring it back to Bell for Wilson McDaniels's wanted poster; the hunt for him comes in the next section.
Why you can lose it
Lost once "Banking, The Old American Art" starts, at the strictest reading; the latest reading keeps the strand open until late in Chapter 6.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Chapter 4: The Gilded Cage, the Heartlands and Roanoke Ridge
The middle of Chapter 4: the mayor's party and the riverboat job in Saint Denis, a Heartlands loop for American Fathers and Oh, Brother, a Roanoke Ridge trip to Van Horn, Annesburg and Doverhill, then a run of Saint Denis strangers that brings Western Stranger, and Horseman 6 from Strawberry back to Saint Denis.
Theatre TicketCollectibleMissablePoint of no return
Location
Bayou Nwa · Saint Denis – During the party, chat with the guests standing about smoking; talking to them earns the ticket. Keep it for the theatre show later in this section.
Why you can lose it
Lost when "The Gilded Cage" ends: the party guests are gone for good.
Point of no return
Finishing "The Gilded Cage": the party guests and the mayor's study are only there during the mission.
Summary
A free pass to a show at the Saint Denis theatre, given out only at the mayor's party.
Algernon's Business CardCollectibleMissablePoint of no return
Location
Bayou Nwa · Saint Denis – By the food table, a top-hatted guest chokes on a nut: help him and he gives you the card. His exotics strand opens after the mission whether or not you have it.
Why you can lose it
Lost when "The Gilded Cage" ends without helping the choking guest.
Point of no return
Finishing "The Gilded Cage": the party guests and the mayor's study are only there during the mission.
Summary
Algernon Wasp's card, from the guest you save from choking; saving him is also the gold's "save a life".
Letter to Bronte from the MayorCollectibleMissablePoint of no return
Location
Bayou Nwa · Saint Denis – Tail the servant into the house and upstairs; he locks a drawer and walks out. The ledger is in that drawer and the letter lies on the desk in the same room: take both.
Why you can lose it
Lost when "The Gilded Cage" ends: the mayor's study can't be entered again.
Point of no return
Finishing "The Gilded Cage": the party guests and the mayor's study are only there during the mission.
Summary
A letter from the mayor to Angelo Bronte, on the desk in the room where the ledger is hidden.
Bayou Nwa · Saint Denis – While Arthur still has it on during the mission, save it as an outfit. It may instead stay only through a glitch, so treat it as a bonus.
Why you can lose it
Lost when "A Fine Night of Debauchery" ends unless it was saved as an outfit (and perhaps even then).
Point of no return
Finishing "A Fine Night of Debauchery" without the Wittemore suit saved as an outfit (whether it can be kept at all is disputed).
Summary
The suit Arthur wears on the riverboat, blue when his honor is high. It is not in the wardrobe afterwards unless it was saved.
Property DeedCollectibleMissablePoint of no return
Location
Heartlands · Central Union Railroad Camp – The camp sits on the new rail line that links Emerald Ranch to the main line. It changes over visits through Chapters 2–6: at the stage where Cornwall's men harass the crew, clear them and take the deed from foreman Percy Whitsickle's table; if that stage hasn't come, look in whenever you pass. Taking it can freeze the camp at that stage until late in the story.
Why you can lose it
No source names a deadline: the route counts it lost once "Banking, The Old American Art" starts, the end of the chapter where it is found.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Summary
A one-off deed on the foreman's table at the Central Union Railroad Camp, once Cornwall's thugs there are driven off.
The Mercies of Knowledge VI–VII: McDaniels and the demonstrationQuest stepMissablePoint of no return
Location
Grizzlies East · Moonstone Pond – With Bell's poster from part V, ride north to Wilson J. McDaniels' camp at Moonstone Pond; it may instead be just north of the railway, below the "N" of "Hanover" on the map. Kill his gang, lasso and hogtie him, and ride him to Bell at the Saint Denis gallows (expect an ambush on the way).
Why you can lose it
The route counts it lost once "Banking, The Old American Art" starts, the strictest reading; the strand may instead stay open until "Our Best Selves" in Chapter 6.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
The end of Chapter 4: the attack on Shady Belle, the trolley job, Lagras and the raid on Bronte, one western trip for the last Horseman ranks and Ms. Hobbs's lists, and the bank job that ends the camp chapters. Read the big warning before the bank.
List of AccountsCollectibleMissablePoint of no return
Location
Bayou Nwa · Saint Denis – On the desk in Bronte's office in the mansion, while you search the rooms.
Why you can lose it
Lost when Revenge is a Dish Best Eaten ends: the desk can't be reached again.
Point of no return
Finishing "Revenge is a Dish Best Eaten": Bronte's office is only open during the mission
Companion activity, Shady Belle (Pearson hunt, Uncle rustling, or Micah/Lenny coach robbery)OtherMissablePoint of no return
Location
Bayou Nwa · Shady Belle – At Shady Belle, go hunting with Pearson, rustle cattle with Uncle, or join Micah's or Lenny's coach robbery. Table games may not count. Offers come at random: if none shows, sleep or check back at other times.
Why you can lose it
Shady Belle's activities end with the camp once 'Banking, The Old American Art' starts.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Summary
One activity with a gang member at each camp builds Friends With Benefits; this is the Shady Belle one.
Friends With BenefitsAchievementMissablePoint of no return
Location
Bayou Nwa · Shady Belle – Pops when the Shady Belle activity ends, if you did one at Horseshoe Overlook and one at Clemens Point.
Why you can lose it
Lost once 'Banking, The Old American Art' starts: the camp activities end with Shady Belle.
Point of no return
Starting "Banking, The Old American Art": it runs straight on to the end of Chapter 4, and the tithing box, item requests and companion activities end with it
Chapter 5 opens on Guarma, a sugar island the gang washes up on. Five missions get them home; before the second rescue job ends, take the seven species that live only here.
Scarlet Macaw: study and skinCollectibleMissablePoint of no return
Location
Guarma · La Capilla – From La Capilla, go to the waterfall near camp, where all three macaws gather. Study it first, then shoot it and pluck the body.
Why you can lose it
Lost with Guarma: free roam on the island ends once both "A Kind and Benevolent Despot" and "Savagery Unleashed" are done, and you can't come back.
Point of no return
Finishing the second of "A Kind and Benevolent Despot" and "Savagery Unleashed" (Guarma free roam ends, strictest reading); "Paradise Mercifully Departed" leaves the island for good
Blue-and-yellow Macaw: study and skinCollectibleMissablePoint of no return
Location
Guarma · La Capilla – At the same waterfall as the Scarlet Macaw: study one before you shoot, then pluck it.
Why you can lose it
Lost with Guarma: free roam on the island ends once both "A Kind and Benevolent Despot" and "Savagery Unleashed" are done, and you can't come back.
Point of no return
Finishing the second of "A Kind and Benevolent Despot" and "Savagery Unleashed" (Guarma free roam ends, strictest reading); "Paradise Mercifully Departed" leaves the island for good
Great Green Macaw: study and skinCollectibleMissablePoint of no return
Location
Guarma · La Capilla – Also at the waterfall by camp: study, shoot and pluck it while you are there.
Why you can lose it
Lost with Guarma: free roam on the island ends once both "A Kind and Benevolent Despot" and "Savagery Unleashed" are done, and you can't come back.
Point of no return
Finishing the second of "A Kind and Benevolent Despot" and "Savagery Unleashed" (Guarma free roam ends, strictest reading); "Paradise Mercifully Departed" leaves the island for good
Red-footed Booby: study and skinCollectibleMissablePoint of no return
Location
Guarma · La Capilla – From the waterfall, follow the river: the booby often flies above it. Study it in the air, then shoot it down and pluck it.
Why you can lose it
Lost with Guarma: free roam on the island ends once both "A Kind and Benevolent Despot" and "Savagery Unleashed" are done, and you can't come back.
Point of no return
Finishing the second of "A Kind and Benevolent Despot" and "Savagery Unleashed" (Guarma free roam ends, strictest reading); "Paradise Mercifully Departed" leaves the island for good
Red Boa Snake: track, study and skinCollectibleMissablePoint of no return
Location
Guarma · La Capilla – Go downhill from La Capilla into the undergrowth under the "E" of Arroyo de la Vibora on the map. One snake waits there at a time: track it (follow its trail in Eagle Eye), study it, then kill and skin it. Leave and let time pass, or save, quit to the menu and resume, and another type appears.
Why you can lose it
Lost with Guarma: free roam on the island ends once both "A Kind and Benevolent Despot" and "Savagery Unleashed" are done, and you can't come back.
Point of no return
Finishing the second of "A Kind and Benevolent Despot" and "Savagery Unleashed" (Guarma free roam ends, strictest reading); "Paradise Mercifully Departed" leaves the island for good
Rainbow Boa Snake: track, study and skinCollectibleMissablePoint of no return
Location
Guarma · La Capilla – At the same snake spot as the Red Boa: keep cycling it (time away or a reload) until a rainbow boa appears, then track it in Eagle Eye, study it, and kill and skin it.
Why you can lose it
Lost with Guarma: free roam on the island ends once both "A Kind and Benevolent Despot" and "Savagery Unleashed" are done, and you can't come back.
Point of no return
Finishing the second of "A Kind and Benevolent Despot" and "Savagery Unleashed" (Guarma free roam ends, strictest reading); "Paradise Mercifully Departed" leaves the island for good
Sunglow Boa Snake: track, study and skinCollectibleMissablePoint of no return
Location
Guarma · La Capilla – Same spot, same cycling; track it in Eagle Eye before you study, kill and skin it. A Fer-de-Lance can turn up here too: it is a required species, listed in the New Austin sweep, and taking it now does no harm.
Why you can lose it
Lost with Guarma: free roam on the island ends once both "A Kind and Benevolent Despot" and "Savagery Unleashed" are done, and you can't come back.
Point of no return
Finishing the second of "A Kind and Benevolent Despot" and "Savagery Unleashed" (Guarma free roam ends, strictest reading); "Paradise Mercifully Departed" leaves the island for good
Sun Hat (Guarma soldiers)ArmorMissablePoint of no return
Location
Guarma · Aguasdulces – In the Aguasdulces shoot-out of A Kind and Benevolent Despot (above), shoot a soldier wearing one so the hat falls off, then pick up the glowing hat. Missed it? Soldiers in Savagery Unleashed wear it too.
Why you can lose it
Only Guarma's soldiers wear it: the route counts it lost when Guarma free roam ends, and the island can't be revisited.
Point of no return
Finishing the second of "A Kind and Benevolent Despot" and "Savagery Unleashed" (Guarma free roam ends, strictest reading); "Paradise Mercifully Departed" leaves the island for good
The rest of Chapter 5: the return to Lemoyne, the gang regrouped at Lakay, two missions in Saint Denis, and the search for a new camp that opens Chapter 6.
Chapter 6: Beaver Hollow
Chapter 6 from the Beaver Hollow camp: the chapter's honor missions and strangers, a ring of jobs from Roanoke Ridge to the Grizzlies and Cumberland Forest, and the chapter's final missions.
Liability AgreementCollectibleMissablePoint of no return
Location
Roanoke Ridge · Butcher Creek – On a table in the village after the closing scene, beside the $50 reward: take both before you ride off.
Why you can lose it
Lost if you leave Butcher Creek without it after part V; strangers can't be replayed.
Point of no return
Leaving Butcher Creek after "The Wisdom of the Elders" V without the agreement on the table
The Course of True Love IVQuest stepMissablePoint of no return
Location
Scarlett Meadows · Braithwaite Manor – Her letter turns up in Arthur's tent at Beaver Hollow after a Chapter 6 story mission (sleep or travel if it isn't there yet). Ride, or take the camp map, to Braithwaite Manor and find her in the cabin behind it, above the river near the gazebo.
Why you can lose it
Lost once "Our Best Selves" starts, and with it Lending a Hand.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
The Course of True Love VQuest stepMissablePoint of no return
Location
Scarlett Meadows · Rhodes – It runs on from part IV: escort Penelope to Rhodes station (cut straight across the fields), brawl with Beau's cousins, then hold off the riders from the train and drive it to Riggs Station. There, accept Penelope's bracelet (next item).
Why you can lose it
Lost once "Our Best Selves" starts, and with it Lending a Hand.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Penelope's BraceletCollectibleMissablePoint of no return
Location
Big Valley · Riggs Station – At Riggs Station at the end of part V, accept it when she offers. Accepting may raise honor (refusing may instead be what does); either way the change is small.
Why you can lose it
Refusing it at Riggs Station loses it for good.
Point of no return
Answering Penelope at Riggs Station at the end of "The Course of True Love V"
The Widow of Willard's Rest IQuest stepMissablePoint of no return
Location
Roanoke Ridge · Willard's Rest – Ride north out of Annesburg to the stranger marker by a grave outside Willard's Rest. Track and shoot a rabbit with her, then kill the two wolves on the walk back to her cabin.
Why you can lose it
Lost once "Our Best Selves" starts at the strictest reading: the full strand belongs to Chapter 6. A shorter form of it may stay open later.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Summary
A grieving widow, Charlotte Balfour, wants to learn to hunt: an optional stranger whose full story plays out in Chapter 6.
Do Not Seek Absolution IQuest stepMissablePoint of no return
Location
Roanoke Ridge · Annesburg – Edith's marker (ED) is on the north side of Annesburg; it only appears with honor at level 4 of 8 or more. She sends you up to the mine.
Why you can lose it
Lost once "Our Best Selves" starts, and with it Lending a Hand.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Summary
Help Edith Downes's son Archie against the foreman at the Annesburg mine, an honor mission for Lending a Hand. Gold: finish inside 1:20.
Do Not Seek Absolution IIQuest stepMissablePoint of no return
Location
Roanoke Ridge · Annesburg – A few in-game hours later Archie waits in Annesburg; ride out to Manito Glade to reach her, but keep away from the hermit's fenced cabin with Keep Out signs (his Rare Shotgun waits for the post-story Roanoke Ridge sweep). Help them both for the honor.
Why you can lose it
Lost once "Our Best Selves" starts, and with it Lending a Hand.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Money Lending and Other Sins VI & VIIQuest stepMissablePoint of no return
Location
Roanoke Ridge · Beaver Hollow – Take it from Strauss at Beaver Hollow. Find J. John Weathers by Moonstone Pond, west of camp (bring a rifle: soldiers arrive), then ask for Londonderry at the Annesburg mine and visit his widow's cabin a short ride south. Absolve both debts, give the widow money, and go back to Strauss.
Why you can lose it
At the strictest reading lost once "My Last Boy" starts (others say "Our Best Selves"), and it can vanish if "Mrs. Sadie Adler, Widow" is done first.
Point of no return
Starting "My Last Boy"
Summary
Strauss's last two debts, then Arthur throws him out of camp. Honor mission (Lending a Hand); no medal, and a large honor gain.
The Widow of Willard's Rest IIQuest stepMissablePoint of no return
Location
Roanoke Ridge · Willard's Rest – A few days after part I, ride back to her cabin at Willard's Rest. Coach her through the bottles (the rat that runs past is optional, and shooting it only earns a jibe) and stay for the meal.
Why you can lose it
Lost once "Our Best Selves" starts.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Letter from CharlotteCollectibleMissablePoint of no return
Location
Roanoke Ridge · Willard's Rest – When part II ends you wake in her cabin: take the letter, and the money from the box on the nightstand, before you leave.
Why you can lose it
Only part II, in Chapter 6, gives it, so it is lost once "Our Best Selves" starts.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Of Men and AngelsQuest stepMissablePoint of no return
Location
Bayou Nwa · Saint Denis – Take the camp map to Saint Denis for the next mission and find her (SC) outside the cathedral first. Give $10 or four food items. It only appears if you did Brothers and Sisters, One and All in Chapter 4.
Why you can lose it
Lost once "The Fine Art of Conversation" starts, and with it Lending a Hand.
Point of no return
Starting "The Fine Art of Conversation"
Summary
Sister Calderón collects for the poor outside the cathedral. Honor mission (Lending a Hand); part II finishes on the spot.
The Widow of Willard's Rest IIIQuest stepMissablePoint of no return
Location
Roanoke Ridge · Willard's Rest – A few days after part II, go back to her cabin at Willard's Rest. She lets you take anything from the cabin: the Premium Cigarettes are worth it (cards).
Why you can lose it
Lost once "Our Best Selves" starts.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Wild Man's JournalCollectibleMissablePoint of no return
Location
Roanoke Ridge · Old Tomb – From Willard's Rest, ride west to the Old Tomb, north-west of Annesburg inside the river bend, and keep passing it until the Feral Man has run from you twice. On the third meeting, track him to his cave, fight off his wolves (killing them or him costs a little honor) and pick up the journal. Leave the Ancient Viking Comb in the tomb: taken now, it is gone after Chapter 6, and the Roanoke sweep collects it.
Why you can lose it
No source names a deadline, so the route counts it lost once "Our Best Selves" starts.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Summary
A one-off journal in the cave of the Feral Man, a naked hermit who runs with wolves.
Military Mountie Hat (army soldiers)ArmorMissablePoint of no return
Location
Cumberland Forest · Favored Sons canyon – In the canyon fight of Favored Sons, soldiers wear it: shoot one so his hat falls, and pick it up before the mission moves on. Missed it? Soldiers in The King's Son and My Last Boy wear it too, as does a guard in Archeology for Beginners, where a kill costs the Owl Feather Trinket.
Why you can lose it
Only the army wears it, in this chapter's missions up to "My Last Boy"; the route counts it lost once "Our Best Selves" starts.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Archeology for BeginnersQuest stepMissablePoint of no return
Location
Grizzlies East · Wapiti Indian Reservation – Rains Fall (RF) at his tent in Wapiti; only there if you said yes in A Rage Unleashed. Kill no one at the camp (the trinket needs it), and agree to help Captain Monroe on the ride back: Honor, Amongst Thieves needs it.
Why you can lose it
Lost if you turn Charles down in "A Rage Unleashed", and once "Our Best Selves" starts.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Honor, Amongst ThievesQuest stepMissablePoint of no return
Location
Cumberland Forest · Wapiti Indian Reservation – Monroe (CM) at Wapiti; the vaccine wagon is in Cumberland Forest.
Why you can lose it
Lost if you don't agree to help Monroe in "Archeology for Beginners", and, at the strictest reading, once "The Fine Art of Conversation" starts: Monroe leaves at its end.
Captain Monroe asks Arthur to steal back vaccines meant for the reservation, an honor mission for Lending a Hand. Gold: take the vaccine undetected; finish inside 5:00.
Letter to Martin from FatherCollectibleMissablePoint of no return
Location
Cumberland Forest · Fort Wallace – Loot a soldier you drop inside Fort Wallace during The King's Son, before you free Eagle Flies. Any Army soldier may carry it instead.
Why you can lose it
At the strictest reading only the Fort Wallace soldiers in "The King's Son" carry it.
Point of no return
Finishing "The King's Son" without looting a Fort Wallace soldier
Mrs. Sadie Adler, WidowQuest stepMissablePoint of no return
Location
Big Valley · Hanging Dog Ranch – Sadie (SA) throws knives at Beaver Hollow once Favored Sons, The Delights of Van Horn and The Bridge to Nowhere are done and few missions are open. Say yes, and ride with her to Hanging Dog Ranch.
Why you can lose it
Lost once "Our Best Selves" starts, and with it Lending a Hand.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
Sadie wants to finish the O'Driscolls at Hanging Dog Ranch, an honor mission for Lending a Hand (medal on part II). Gold: headshot the barn sniper; take the barn unhurt; finish inside 5:30.
Lending a HandAchievementMissablePoint of no return
Location
Big Valley – Pops once the last one is done; on this route that is Mrs. Sadie Adler, Widow, after the Chapter 2–4 ones and this chapter's honor missions above.
Why you can lose it
Lost if any honor mission is missed; this chapter's last ones close when "Our Best Selves" starts.
Point of no return
Starting "Our Best Selves" (it runs straight into the last mission of Chapter 6)
The first part of the Epilogue, on a cattle ranch in Big Valley: ranch work, trouble with a local gang, the last part of The Veteran and a new stranger strand, ending with a land deal in Blackwater.
Worn Flat CapHidden spoiler – activate to revealArmorMissablePoint of no returnMajor spoiler
Location
Big Valley · Strawberry – Fighting is limited in this mission, so let an animal do it: slap one of the horses in Strawberry on the rear until it kicks you, then pick the cap up before the mission ends.
Why you can lose it
At the strictest reading it can only be saved during "The Wheel".
John's Gambler's HatHidden spoiler – activate to revealArmorMissablePoint of no returnMajor spoiler
Location
Big Valley · Pronghorn Ranch – Right after the mission, pick a fight with someone on the road beside the ranch, or slap a horse on the rear until it kicks you, then pick the hat up.
Why you can lose it
No source names a deadline; at the strictest reading it is lost once another hat replaces it.
Point of no return
Putting on any other hat before the gambler hat is saved (strictest reading)
The second part of the Epilogue: building a home on the Great Plains with old friends, jobs from Saint Denis to New Austin and Tall Trees, and the last mission before the credits.
Item request: Charles, an eagle featherHidden spoiler – activate to revealOtherMissablePoint of no returnMajor spoiler
Location
Great Plains · Beecher's Hope – Shoot any eagle and pluck a feather: golden eagles live in the mountains of West Elizabeth and Ambarino, and both kinds perch on the Bard's Crossing rail bridge over the Dakota. Hand it to Charles at Beecher's Hope.
Why you can lose it
Lost once "American Venom" starts: Charles's request ends with it.
The desert state that opens only after the story: from Thieves' Landing west through Hennigan's Stead, Armadillo and Cholla Springs, along the Rio Bravo past Fort Mercer, and out to Tumbleweed and Gaptooth Ridge.
Letter to Zhou Yi from Zhou WeiCollectibleMissablePoint of no return
Location
Cholla Springs · Armadillo – Search Zhou Yi's body, curled up at the camp, before you leave.
Why you can lose it
Lost if you leave Zhou Yi's camp without searching him: his body can't be counted on to be there later.
Point of no return
Riding away from Zhou Yi's camp without searching his body
Summary
A letter from Zhou Yi's family, a one-off document for the journal.
A clockwise ride through the eastern Grizzlies: Hotah, a ledge bone and the monk above Fort Wallace at Cotorra Springs, the high north-east around the Loft, Bharati at O'Creagh's Run, Moonstone Pond, then Donner Falls and the hill house above Cumberland Forest.
Note from the SculptorCollectibleMissablePoint of no return
Location
Grizzlies East · Moonstone Pond – Shoot the rope the sculptor hangs from so his body drops, then loot the note from him before you leave.
Why you can lose it
Lost if you leave the carved face without looting the sculptor: his body can't be counted on to be there later.
Point of no return
Leaving the Face in Cliff with the sculptor's body unlooted
Summary
The sculptor's last letter, a one-off document for the journal.
Sweep: The Heartlands: Flatneck Station, the oil fields and Emerald Ranch
Up the Dakota from Bard's Crossing to Limpany and Horseshoe Overlook, down the railway to Flatneck Station and Gill Landing, across the open Heartlands to Larned Sod and the oil fields, round the Heartland Overflow, and on to Emerald Ranch and Emerald Station.
Letter from Cornwall Kerosene & TarCollectibleMissablePoint of no return
Location
Heartlands · Oil Derrick – Loot it from Mr. Varley's burnt body at the derrick before you do anything else here.
Why you can lose it
Lost if you leave the derrick without looting Mr. Varley's body: his body can't be counted on to be there later.
Point of no return
Leaving the Oil Derrick with Mr. Varley's body unlooted
Summary
A one-off journal document: the threatening letter from Cornwall's vice-president, Cameron Spence, to the derrick's owner.
Sweep: Roanoke Ridge: Annesburg and the north-east
A loop through northern Roanoke Ridge: Clingman, the Grizzlies East border and Brandywine Drop, the upper Kamassa for two legendaries, Deer Cottage, the Old Tomb and Manito Glade, then Annesburg and the hills south-west of town.
Rare ShotgunWeaponMissablePoint of no return
Location
Roanoke Ridge · Manito Glade – Ride back east past Deer Cottage toward Annesburg and take the right-hand road north of town to Manito Glade, a fenced cabin with Keep Out signs. The hermit comes out shouting and fires if you keep coming: lasso and hogtie him (or punch the gun from his hands). Pick the shotgun up off the ground at once.
Why you can lose it
Lost if you walk away without picking it up once the hermit is dealt with: it can't be collected later, and he may leave for good after a third meeting.
Point of no return
Leaving Manito Glade after dealing with the hermit without picking up his Rare Shotgun (he may also leave for good after a third meeting)
Summary
A unique engraved double-barrelled shotgun, owned by the Manito Glade hermit.
A loop through the city by district: the police station, freight hall and docks along the river, the station and the market, the north-east and the slums, the farms past the cemetery, then Harris Square, the theatre and the mansion district. It ends with Algernon's five exotics orders (three need a short trip out first) and a last stop at the post office.
Rare Orchids Order (post office wall)CollectibleMissablePoint of no return
Location
Bayou Nwa · Saint Denis – Ride back to the post office at Victoria Street Station (any post office will do). The list hangs on the wall like a bounty poster; nothing in the game points you to it.
Why you can lose it
Lost if you reload after the game has saved (autosaves count) before taking it: the poster disappears.
Point of no return
Reloading after a save (autosaves count) made after Algernon's final visit, before the Rare Orchids Order is taken from a post office wall
A handwritten list Algernon pins up in post offices once his strand is over; taking it lets you sell orchids by mail. A one-off document for the journal.
What the map sweep leaves: three strand finales, the table-game tour, Ms. Hobbs's last list and the squirrel statue, the last challenge ranks, the Bandit crimes and Bountiful, the 100% counters, then Gold Rush and Best in the West.
Old Brass CompassCollectibleMissablePoint of no return
Location
Big Valley · Sinclair cabin – After the closing scene, go back into the cabin and take the compass from the table before you ride off.
Why you can lose it
Lost if you leave the Sinclair cabin without it after the finale: the door may stay locked.
Point of no return
Leaving the Sinclair cabin after the Geology for Beginners finale without the compass
Fisherman's Hat (Jeremy Gill's hat)Hidden spoiler – activate to revealArmorMissablePoint of no returnMinor spoiler
Location
Rio Bravo · San Luis River – As the mission ends, look along the water's edge for his hat and pick it up, with the Special Spinner. If it lies in the river out of reach, reload the save from before the mission and try again.
Why you can lose it
Lost if, as the mission ends, his hat flies too far into the San Luis River to reach.
Point of no return
The end of "A Fisher of Fish II", when Gill's hat may land in the San Luis River out of reach